Endocrine Abstracts

One in five people in the UK is affected by lung disease, along with millions more worldwide. Glucocorticoids represent the most utilized anti-inflammatory therapy for the treatment of pulmonary inflammation, however a subset of patients exist which do not respond to therapeutically relevant doses.The non-ciliated bronchial epithelial (Clara) cells have been identified as key mediators of the pulmonary inflammatory response. The glucocorticoid receptor (...

Glucocorticoids (GCs) are used extensively in the treatment of inflammatory disease. Unfortunately, as GC act on virtually every organ system they also carry a broad range of serious side-effects which limits their clinical use.The structure of the bound GC strongly impacts the final conformation of the glucocorticoid receptor (GR) and thereby dictates downstream events. Designing drugs with different GR binding properties therefore offers a plausible ro...